Stanford

Therapeutics (SPARK)

SPARK was created as an innovative, cost-effective way to overcome the hurdles associated with translating academic discoveries into drugs or diagnostics that address real clinical needs.


Next-generation selective AAK1 and GAK inhibitors for combating emerging viral infections

Year: 2015
Investigator: Shirit Einav, MD, assistant professor of medicine and of microbiology and immunology; Mark Smith, PhD, ChEM-H senior research scientist; Vijay Pande, PhD, professor of chemistry


Development of novel beta-1-adrenergic receptor agonists as novel medication for Alzheimer’s disease

Year: 2015
Investigator: Mehrdad Shamloo, PhD, associate professor of neurosurgery; Pooneh Memar Ardestani, MD, PhD, postdoctoral scholar in neurosurgery; Bitna Yi, PhD, postdoctoral scholar in neurosurgery; Alam Jahangir, consultant


Developing a novel therapeutic targeting the glucagon-like peptide-1 receptor for treatment of hyperinsulinemic hypoglycemia post-bariatric surgery

Year: 2015
Investigator: Tracey McLaughlin, MD, associate professor of medicine; Colleen Craig, MD, postdoctoral scholar in endocrinology


Development of peptide vaccines for the treatment of glioblastoma using a chemical biology approach

Year: 2015
Investigator: Albert Wong, MD, professor of neurosurgery; Allis Chien, PhD, director of Stanford University Mass Spectrometry


Repurposing of a pump inhibitor as an immune-enabling anti-tuberculosis drug

Year: 2015
Investigator: Niaz Banaei, MD, associate professor of pathology and of medicine; Rajiv Gaur, PhD, pathology research associate


Developing novel inhibitors for the treatment of tuberculosis and clostridium difficile infection

Year: 2015
Investigator: Irimpan Mathews, staff scientist; Irishi Namboothiri, PhD, professor of chemistry at Indian Institute of Technology; Amnon Kohen, PhD, professor of chemistry at the University of Iowa


Repurposing a biologic therapy for treatment of neuromyelitis optica

Year: 2014
Investigator: Alexandra Goodyear, MD, clinical assistant professor of neurology and neurological sciences and Robert Axtell


Repurposing approved drugs against dengue virus

Year: 2014
Investigator: Vijay Pande, PhD, professor of chemistry; Karla Kirkegaard, PhD, professor of microbiology and immunology; Shirit Einav, MD, assistant professor of medicine and of microbiology and immunology


Developing small molecule inhibitors of a novel mTOR target for treatment of tuberous sclerosis complex

Year: 2014
Investigator: Tobias Meyer, PhD, professor of Chemical and Systems Biology


Repurposed drug to treat Alzheimer’s disease via a novel pathway

Year: 2014
Investigator: Mehrdad Shamloo, PhD, associate professor (research) of neurosurgery
Journal article: http://www.ncbi.nlm.nih.gov/pubmed/24883337


Pan-genotypic small molecule inhibitors of influenza A virus

Year: 2014
Investigator: Jeffrey Glenn, MD, PhD, associate professor of medicine and microbiology and immunology; Rachel Hagey, PhD candidate in microbiology and immunology; Rhiju Das, PhD, assistant professor of biochemistry


Repurposing a biologic therapy for treatment of neuromyelitis optica

Year: 2013
Investigator: Alexandra Goodyear, MD, clinical assistant professor of neurology and neurological sciences


Novel therapeutic for familial amyloidosis

Year: 2013
Investigator: Isabella Graef, PhD, assistant professor of pathology
Journal article: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683741/


Therapeutic for Huntington disease via a novel target

Year: 2013
Investigator: Stanley N. Cohen, MD, professor of genetics and medicine


Treatment to prevent graft versus host disease following hematopoietic stem cell transplantation

Year: 2013
Investigator: Everett Meyer, MD, assistant professor of medicine


Novel formulation of a repurposed drug to increase blood vessel regrowth in transplanted organs

Year: 2012
Investigator: Mark Nicolls, MD, Associate Professor of Medicine
Journal article: http://www.ncbi.nlm.nih.gov/pubmed/25727073
Another article in review


Repurposing FK506 (Tacrolimus) to treat pulmonary arterial hypertension

Year: 2012
Investigator: Edda Spiekerkoetter, MD, Assistant Professor of Medicine, and Roham Zamanian, MD, Assistant Professor of Medicine
Journal article: http://www.phaonlineuniv.org/Journal/Article.cfm?ItemNumber=4622
Video: https://www.youtube.com/watch?v=DEReOdPgB8M


Repurposed drug to treat large lymphatic malformations in children

Year: 2012
Investigator: Alfred Lane, MD, Professor of Dermatology
Journal article: http://www.ncbi.nlm.nih.gov/pubmed/24656411
News story: http://med.stanford.edu/news/all-news/2012/02/can-viagra-treat-childhood-lymphatic-disorder.html


Itraconazole clinical study to treat basal cell carcinoma and basal cell nevus syndrome

Year: 2011
Investigator: Jean Tang, MD, PhD, Associate professor of dermatology
News article: http://med.stanford.edu/ism/2013/january/vismo-0114.html
Journal articles:
http://www.ncbi.nlm.nih.gov/pubmed/20385363
http://www.ncbi.nlm.nih.gov/pubmed/24493717


Repurposed drug for post-operative pain

Year: 2011 Investigators: Robert Lobato, MD, and Gary Peltz, MD, PhD, Professor of Anesthesiology, Perioperative and Pain Medicine


Novel therapeutic for treatment and prevention of muscle atrophy

Year: 2011
Investigator: Joseph Shrager, MD, Professor of Cardiothoracic Surgery
Journal article: http://sfx.stanford.edu/local?sid=stanford:laneweb-search-pubmed&id=pmid:24570486


Blood biomarker for “chemo brain” in cancer patients 


Year: 2010
Investigator: Gilbert Chu, MD, PhD, Professor of Medicine and of Biochemistry


Novel topical biologic for burn healing 


Year: 2010
Investigator: Nicholas Evans, PhD 



On-chip isotachophoresis device for nucleic acid purification and profiling

Year: 2010 Investigators: Juan Santiago, PhD, professor of mechanical engineering, and Calvin Kuo, MD, PhD, Professor of medicine


Itraconazole clinical study to treat basal cell carcinoma and basal cell nevus syndrome

Year: 2010
Investigator: Jean Tang, MD, PhD, Associate professor of dermatology
Journal articles:
http://www.ncbi.nlm.nih.gov/pubmed/20385363
http://www.ncbi.nlm.nih.gov/pubmed/24493717


Need Help Getting Started?

Education & Mentoring Program:
   Anandi Krishnan, PhD  email

Research training, events, and workshops:
   Jessica P. Meyer  email
   (650) 498-6140

To find mentors, research jobs, and fellowships, log-in to CAP Network.